2025 AOFAS Annual Meeting-Paper Session 1C

Video Transcription

Video Summary

The session featured presentations on innovative treatments and research related to foot and ankle conditions. Dr. El-Amin presented a double-blind, placebo-controlled study on collagenase Clostridium histolyticum (CCH) injections for plantar fibromatosis (PFI), demonstrating significant improvements in pain, nodule hardness, and patient satisfaction, particularly in those with more severe nodules, and confirming the treatment’s safety profile. Dr. Roberto Zambelli discussed the use of artificial intelligence (AI) models analyzing clinical and laboratory data to predict amputation risk in diabetic foot ulcer (DFU) patients. His models showed high accuracy in forecasting both the need for amputation and the level of amputation, aiming to personalize treatment and resource use. Matthew presented a limb salvage case using horizontal fibular transport combined with a 3D-printed scaffold to manage a large tibial defect in a diabetic patient, enabling eventual weight-bearing without microvascular surgery. Jonathan Day’s cadaveric micro-CT study identified key talar microvasculature vulnerable to injury during subtalar and talonavicular fusions, highlighting surgical risk factors for nonunion. Finally, Dr. Wildecker reviewed osteomyelitis treatments and healing rates, noting better outcomes in chronic versus acute cases. The session concluded with Q&A discussing injection techniques for CCH, clinical use of AI models, advantages of fibular transport versus microvascular grafts, surgical approaches preserving talar blood supply, and patient selection for PFI treatment.

Keywords

collagenase Clostridium histolyticum

plantar fibromatosis

double-blind placebo-controlled study

artificial intelligence in diabetic foot ulcer

amputation risk prediction

horizontal fibular transport

3D-printed scaffold

talar microvasculature injury

osteomyelitis treatment outcomes