CME OnDemand: 2022 AOFAS Annual Meeting-The Statistical Fragility of Platelet-Rich Plasma as Treatment for Plantar Fasciitis: A Systematic Review and Simulated Fragility Analysis-_AOFAS_2022

The Statistical Fragility of Platelet-Rich Plasma as Treatment for Plantar Fasciitis: A Systematic Review and Simulated Fragility Analysis-_AOFAS_2022_e-Poster

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This study conducted a systematic fragility analysis of Platelet-Rich Plasma (PRP) for Plantar Fasciitis. The researchers examined the fragility index (FI) and fragility quotient (FQ) to assess the importance of patient follow-up in evaluating the efficacy of PRP treatment. <br /><br />The FI was found to be 9 patients, indicating that if nine patients with positive outcomes were to change their status, the statistical significance of the treatment would no longer hold. The mean sample size of the study was 52.7 patients, and 27.8% of outcome events were lost due to follow-up issues. <br /><br />The fragility quotient (FQ) was calculated to be 0.171, which represents the number of patients lost to follow-up. The study emphasizes the importance of reporting fragility indices alongside p-values in order to provide a more comprehensive understanding of the strength of statistical findings. <br /><br />The research was conducted by a team from Johns Hopkins University, specifically the Department of Orthopaedic Surgery.

Asset Subtitle

Arjun Gupta, BS, Carlos Ortiz-Babilonia, BS, Amy L. Xu, BS, Davis Rogers, MD, Ettore Vulcano, MD, Amiethab A. Aiyer, MD

Keywords

Platelet-Rich Plasma

Plantar Fasciitis

fragility analysis

fragility index

fragility quotient

patient follow-up

efficacy of PRP treatment

sample size

outcome events

fragility indices