Specialty Day 2020 - Paper Presentations-The Intra-articular Hematoma Immediately After Ankle Fracture Causes Cartilage Damage That Is Partially Attenuated by Anti-inflammatory Agents

The Intra-articular Hematoma Immediately After Ankle Fracture Causes Cartilage Damage That Is Partially Attenuated by Anti-inflammatory Agents

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Video Transcription

Video Summary

In this video, Samuel Adams discusses the link between intraarticular hematoma immediately after ankle fracture and cartilage damage. He explains that ankle fractures often lead to ankle arthritis, and while many believe the cartilage damage is caused by the injury itself, he suggests that inflammation from the healing fracture may be to blame. Adams presents the results of a study that examined the effect of the fracture hematoma on cartilage discs and found that exposure to the hematoma led to increased production of inflammatory cytokines and MMPs, which degrade cartilage. However, the study also showed that the use of anti-inflammatory and anti-MMP agents reduced cartilage damage caused by the hematoma.

Asset Subtitle

Samuel B. Adams, MD; Nicholas Allen; Bijan Abar

Keywords

Samuel Adams

intraarticular hematoma

ankle fracture

cartilage damage

inflammatory cytokines